| Abstract: | Abstract Materials with unique complex of the properties of elasticity and tensile strength processed from the natural rubber latex (NRL) were modified to improve their blood compatibility. ESCA, ATR-IR, UV-spectroscopy and other methods were used for appraisement of the grade of modification, structure and properties of material. Thromboresistancy was studied in in vivo and ex vivo tests. It was shown that blood compatibility is raised after thorough purification of the material from non-rubber components by means of two-stage extraction changing the physical-chemical parameters of the surface. Two different principles were used in the process of modification: 1) coating by thin polyurethane (PU) coverings with improved thromboresistant properties-thus the problem of providing high adhesion interaction of covering with the latex base was solved; 2) heparin surface immobilization-higher efficiency of modification of latex material in gel-form without preliminary protein adsorption was shown. Modification allows to increase blood compatibility of the latex materials preserving at the same time their elasticity and tensile strength. |
