| 细支气管肺泡癌患者EGFR基因突变的研究 |
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| 引用本文： | 蔡振丽,王凯,宋欣,李向红,伍志强,韩为东,赵亚力.细支气管肺泡癌患者EGFR基因突变的研究[J].压电与声光,2010(1):58-60. |
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| 作者姓名： | 蔡振丽 王凯 宋欣 李向红 伍志强 韩为东 赵亚力 |
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| 作者单位： | [1]解放军总医院基础所分子生物室,北京100853 [2]蚌埠医学院生物科学系,蚌埠233030 [3]解放军总医院病理科,北京100853 |
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| 基金项目： | 国家科技部“中国人类遗传资源共享平台建设”项目(DKA30490);;军队“十一五”科研基金项目(06G106)~~ |
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| 摘 要： | 目的探讨表皮生长因子受体（EGFR）基因酪氨酸激酶域体细胞在细支气管肺泡癌（BAC）患者中突变的相关因素。方法分析和检测本院37例细支气管肺泡癌石蜡包埋标本EGFR基因突变状况，采用PCR技术进行EGFR基因18、19、20和21外显子突变分析。结果37例BAC患者中有18例（48．6％）酪氨酸激酶域存在体细胞突变，其中3例（8．1％）为18外显子替代突变，5例（13．5％）为19外显子突变，7例（18．9％）为20外显子替代突变，8例（21．6％）为21外显子替代突变。结论EGFR基因与BAC密切相关。
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| 关 键 词： | 腺癌 细支气管肺泡 受体 表皮生长因子 突变 基因 |
Epidermal growth factor receptor mutation in bronchioloalveolar carcinoma |
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| CAI Zhen-li,WANG Kai,SONG Xin,LI Xiang-hong,WU Zhi-qiang,HAN Wei-dong,ZHAO Ya-li.Epidermal growth factor receptor mutation in bronchioloalveolar carcinoma[J].Piezoelectrics & Acoustooptics,2010(1):58-60. |
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| Authors: | CAI Zhen-li WANG Kai SONG Xin LI Xiang-hong WU Zhi-qiang HAN Wei-dong ZHAO Ya-li |
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| Affiliation: | CAI Zhen-li,WANG Kai,SONG Xin,LI Xiang-hong,WU Zhi-qiang,HAN Wei-dong,ZHAO Ya-li1Department of Molecular Biology,Institute of Basic Medicine,Chinese PLAGeneral Hospital,Beijing100853,China,2Department ofBiological Science at Bengbu Medical College,Bengbu 233030,3Department of Pathology,Chinese PLA General Hospital,Beijing 100853 |
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| Abstract: | ObjectiveTo study the somatic mutation of tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR gene)in bronchioloalveolar carcinoma (BAC) patients.MethodsMutational analysis for EGFR exons 18 -21 was performed in 37 BAC patients.ResultsSomatic mutations in the TKdomain of EGFR were identified in 18 of the 37(48.6%) patients, including3 cases of amino acid substitution in exon 18 (8.1%), 5 cases in exon 19(13.5%), 7 cases of amino acid substitution in exon 20(18.9%) and8 cases of amino acid ... |
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| Keywords: | Adenocarcinoma Bronchiolo-Alveolar Receptor Epidermal Growth Factor Mutation Genes |
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