| “一锅法”合成4-二甲氨基吡啶 |
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| 引用本文： | 陈国广,赵欣,张大永.“一锅法”合成4-二甲氨基吡啶[J].精细化工,2006,23(5):518-520. |
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| 作者姓名： | 陈国广 赵欣 张大永 |
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| 作者单位： | 1. 南京工业大学,制药与生命科学学院,江苏,南京,210009
2. 南京师范大学,化学与环境科学学院,江苏,南京,210097 |
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| 摘 要： | 以4-氰基吡啶、2-乙烯基吡啶和二甲胺为主要原料,一锅法合成了4-二甲氨基吡啶。得出的最佳工艺条件为:反应物配料比m(4-氰基吡啶)/m(2-乙烯基吡啶)=1.5,使用w(NaOH)=40%的水溶液回流2 h裂解中间体,反应产率达87.4%。目标化合物通过IR、1HNMR及MS确认。
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| 关 键 词： | 4-二甲氨基吡啶 4-氰基吡啶 2-乙烯基吡啶 一锅法 |
| 文章编号： | 1003-5214（2006）05-0518-03 |
| 收稿时间： | 2005-08-21 |
| 修稿时间： | 2005-08-212005-11-03 |
‘One Pot’ Method for Synthesis of 4-Dimethylaminopyridine (DMAP) |
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| CHEN Guo-guang,ZHAO Xin,ZHANG Da-yong.‘One Pot’ Method for Synthesis of 4-Dimethylaminopyridine (DMAP)[J].Fine Chemicals,2006,23(5):518-520. |
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| Authors: | CHEN Guo-guang ZHAO Xin ZHANG Da-yong |
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| Affiliation: | 1. School of Life Science and Pharmaceutical Engineering, Nanjiing University of Technology , Nanjing 210009, Jiangsu , China; 2. School of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, Jiangsu, China |
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| Abstract: | 4-Dimethylaminopyridine(DMAP) was prepared by 'one pot' method with 4-cyanopyridine,2-vinylpyridine and dimethylamine(DMA).The optimum conditions were given:m(4-cyanopyridine)/m(2-vinylpyridine)=1.5,and w(NaOH)=40% sodium hydroxide solution was added to decompose the intermediate under reflux for 2 h.Overall yield of the product reached 87.4% and 2-vinylpyridine could be recovered.The structure of target compound was confirmed by IR,~1HNMR and MS. |
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| Keywords: | 4-dimethylaminopyridine 4-cyanopyridine 2-vinylpyridine 'one pot' method |
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