Effects of priming for audiogenic seizures in mice as a function of genotype and sound intensity.

Studied the effects of sound-intensity levels and genotypes on priming for audiogenic seizures in 367 mice of the BALB/c, C57BL/J Rubbo, and C57BL/K Bradley strains and their F1 hybrids. Significant main effects for Strain, Sound Intensity, and Genotype * Treatment interaction, and a variability of mode of inheritance, depending upon particular genotypes and treatments, were observed. A 96-db sound was not effective in inducing seizure susceptibility in all genotypes; a 101-db sound induced moderate seizure rate in BALB/c and K Bradley Ss but not in the other strains; a 104-db sound induced a high seizure rate in BALB/c, but a moderate rate in K Bradley and BALB/c * J Rubbo Ss; at 109-db level, a high seizure rate was induced in BALB/c and BALB/c * J Rubbo Ss and a moderate rate in K Bradley. (23 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)