| mPEG接枝葡聚糖偶联肉桂醛的合成及pH敏感释放 |
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| 引用本文： | 陶丽,姚日生,刘璐,李曼曼.mPEG接枝葡聚糖偶联肉桂醛的合成及pH敏感释放[J].安徽化工,2009,35(4):22-26. |
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| 作者姓名： | 陶丽 姚日生 刘璐 李曼曼 |
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| 作者单位： | 合肥工业大学化学工程学院,安徽,合肥,230009;合肥工业大学化学工程学院,安徽,合肥,230009;农产品生物化工教育部工程研究中心,安徽,合肥,230009 |
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| 摘 要： | 采用高碘酸钠氧化葡聚糖制成聚醛基葡聚糖，以己二酰肼为间隔臂，通过生成腙键分别偶联肉桂醛，接枝醛化mPEG。透射电镜观察该偶联物在水相中可自组装成粒径为200～300nm的纳米胶束。紫外跟踪检测在pH为5．4、6．8、7．4缓冲液中的释放行为，显示肉桂醛的释放速率v（pH=5．4）〉〉v（pH=6．8）〉v（pH=7．4）。所制该载药隐形纳米粒将可借助EPR效应被动靶向富集于肿瘤组织；在拟肿瘤细胞溶酶体pH≈5．4环境下可敏感释药，因而将具备一定的肿瘤靶向释药性能。
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| 关 键 词： | 肉桂醛 葡聚糖 单甲氧基聚乙二醇 肿瘤靶向 |
Synthesis and pH Sensitive Release of Conjugate of Dextran Coupled with Cinnamyl Aldehyde and Grafted with mPEG |
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| TAO Li,YAO Ri-sheng,LIU Lu,LI Man-man.Synthesis and pH Sensitive Release of Conjugate of Dextran Coupled with Cinnamyl Aldehyde and Grafted with mPEG[J].Anhui Chemical Industry,2009,35(4):22-26. |
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| Authors: | TAO Li YAO Ri-sheng LIU Lu LI Man-man |
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| Affiliation: | TAO Li1,YAO Ri-sheng1,2,LIU Lu1,LI Man-man1 (1. Chemical Engineering College,Hefei University of Technology,Hefei 230009,China,2. Engineering Research Center of Bio-process of Ministry of Education,China) |
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| Abstract: | A new drug delivery system of Dextran coupled with Cinnamyl aldehyde and grafted with mPEG, by the bond of hydrazone which was sensitive to pH=5.4 weak acidic environment was designed and prepared. The conjugate could assemble to nanoparticle with the diameter of 200-300nm in water, and then might beneficiate passively to tumor tissue through the effect of EPR. The release rate of cinnamyl aldehyde from the conjugate showed the tendency of v （pH=5.4） 〉〉v（pH=6.8）〉v（pH=7.4）. It meant that the prepared structure of conjugate might be unstable to the acidic environment of tumor cell and the drug would be released sensitively. |
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| Keywords: | Cinnamyl aldehyde Dextran Monomethoxypoly(ethylene glycol) tumor-targeted |
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