Synthesis and characterization of biocompatible hydroxyapatite coated ferrite |
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Authors: | S Deb J Giri S Dasgupta D Datta D Bahadur |
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Affiliation: | (1) Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology, 400 076 Mumbai, India;(2) School of Biomedical Engineering, Indian Institute of Technology, 400 076 Mumbai, India |
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Abstract: | Ferrite particles coated with biocompatible phases can be used for hyperthermia treatment of cancer. We have synthesized substituted
calcium hexaferrite, which is not stable on its own but is stabilized with small substitution of La. Hexaferrite of chemical
composition (CaO)0.75(La203)0.20(Fe2O3)6 was prepared using citrate gel method. Hydroxyapatite was prepared by precipitating it from aqueous solution of Ca(NO3)2 and (NH4)2HPO4 maintaining pH above 11. Four different methods were used for coating of hydroxyapatite on ferrite particles. SEM with EDX
and X-ray diffraction analysis shows clear evidence of coating of hydroxyapatite on ferrite particles. These coated ferrite
particles exhibited coercive field up to 2 kOe, which could be made useful for hysteresis heating in hyperthermia. Studies
by culturing BHK-21 cells and WBC over the samples show evidence of biocompatibility. SEM micrographs and cell counts give
clear indication of cell growth on the surface of the sample. Finally coated ferrite particle was implanted in Kasaulli mouse
to test its biocompatibility. The magnetic properties and biocompatibility studies show that these hydroxyapatite coated ferrites
could be useful for hyperthermia. |
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Keywords: | Bioceramics hyperthermia ferrite biocompatible coating |
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