Percutaneous absorption of dodecyltrimethylammonium bromide, a cationic surfactant, in the rat |
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| Authors: | F G Bartnik F Wingen |
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| Affiliation: | 1. Department of Molecular Biosciences, 1089 Veterinary Medicine Dr., VM3B, UC Davis, CA 95616, USA;2. Department of Pathology, Microbiology, and Immunology, 4206 Veterinary Medicine Dr., VM3A, UC Davis, CA 95616, USA;1. Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China;2. Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, United States;3. School of Physical Science and Technology, Shanghai Tech University, Shanghai 200031, PR China;4. School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China;1. Jiangsu Key Laboratory of Precious Metals Chemistry and Engineering, School of Chemistry and Environment Engineering, Jiangsu University of Technology, Changzhou, 213001, China;2. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan, 430062, China;3. Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, 230026, China;1. Department of Botany, Hansraj College, University of Delhi, Delhi 110007, India;2. Department of Zoology, Hansraj College, University of Delhi, Delhi 110007, India;3. Faculty of Forestry and Wood Sciences, Czech University of Life Sciences, Prague, Kamýcká 129, Suchdol, 165 21 Prague 6, Czech Republic;4. Molecular Biology Research Lab, Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, New Delhi 110019, India;5. Delhi School of Climate Change and Sustainability, Institution of Eminence, Maharishi Karnad Bhawan, University of Delhi, Delhi, India |
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| Abstract: | ![]()
The route and rate of excretion of the cationic surfactant [14C]dodecyl-trimethylammonium bromide (DTB) given by parenteral injection were investigated in rats, and the percutaneous absorption of the surfactant through non-occluded rat skin and the resulting blood levels were also studied. The surfactant was applied to the intact clipped skin of rats in aqueous solution or in a hair-rinse formulation. Elimination by the rat after parenteral administration was rapid and was effected primarily via the urine, more than 80% of the radioactivity being eliminated within 24 hr of application. Percutaneous absorption of the surfactant was low. Application in a cream hair-rinse preparation under user conditions resulted in the absorption of about 0·1% of the administered radioactivity in 48 hr. No measurable radioactivity was present in the blood. Application of the surfactant at a higher concentration in aqueous solution gave a somewhat higher absorption (0·6% in 72 hr). Some radioactivity (equivalent to less than 100 ng unchanged DTB/g) was found in the blood after application of the surfactant to the skin without subsequent rinsing. |
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