| 响应面优化魔芋葡甘聚糖缓释尼莫地平药膜 |
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| 引用本文： | 江贵林,汪超,陈文平,陈士勇,吕文平,姜发堂.响应面优化魔芋葡甘聚糖缓释尼莫地平药膜[J].武汉理工大学学报,2010(1). |
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| 作者姓名： | 江贵林 汪超 陈文平 陈士勇 吕文平 姜发堂 |
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| 作者单位： | 湖北工业大学生物工程学院;武汉力诚生物科技有限公司; |
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| 基金项目： | 湖北省教育厅(20063036); 武汉市科技局晨光计划(20065004116-52) |
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| 摘 要： | 以魔芋葡甘聚糖(KGM)为缓释药膜,分析模型药物—尼莫地平的体外释放特性。筛选并确定KGM浓度、DM-SO添加量、载药混合时间和静置时间4个因素的中心组合试验设计,以尼莫地平(NMP)的缓释度为考察指标,采用响应面优化KGM缓释药膜的制备工艺。结果表明:4个因素对药膜缓释尼莫地平均有显著影响,依次为静置时间>KGM浓度>DMSO添加量>载药混合时间,且最优条件为3.0%(w/v)KGM、0.5 mL DMSO、载药混合12 min、静置77 min。制备的药膜表面平整光滑,载药量为(1.63±0.01)%,尼莫地平缓释度为93.169%。
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| 关 键 词： | 魔芋葡甘聚糖 缓释药膜 尼莫地平 响应面分析 |
Optimization of Konjac Glucomannan Release Nimodipine Membrane by Response Surface Analysis |
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| JIANG Gui-lin,WANG Chao,CHEN Wen-ping,CHEN Shi-yong,LV Wen-ping,JIANG Fa-tang.Optimization of Konjac Glucomannan Release Nimodipine Membrane by Response Surface Analysis[J].Journal of Wuhan University of Technology,2010(1). |
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| Authors: | JIANG Gui-lin WANG Chao CHEN Wen-ping CHEN Shi-yong LV Wen-ping JIANG Fa-tang |
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| Affiliation: | JIANG Gui-lin1,WANG Chao1,2,CHEN Wen-ping1,CHEN Shi-yong1,LV Wen-ping1,JIANG Fa-tang1,2 (1.School of Biological Engin.,Hubei University of Technology,Wuhan 430068,China,2.Wuhan Licheng Biotechnology Co.Ltd,China) |
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| Abstract: | The invitro release properties of NMP were analyzed by konjac glucomannan membrane.The preparation parameters were investigated by evaluation of the NMP release degree,selected and then confirmed the effects such as concentration of KGM,DMSO,mix time,laying-time,and used response surface analysis to optimize preparation parameters of membrane.The results show that four factors have significant impact on the release degree of NMP,and the order is laying-time > KGM concentration > DMSO > mix time.The optimal ... |
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| Keywords: | konjac glucomannan release membrane nimodipine response surface analysis |
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