Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications |
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| Authors: | Shelby A Skoog Anirudha V Sumant Nancy A Monteiro-Riviere Roger J Narayan |
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| Affiliation: | (1) Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Box 7115, Raleigh, NC 27695-7115, USA;(2) Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL, USA;(3) Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA; |
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| Abstract: | Ultrananocrystalline diamond (UNCD) exhibits excellent biological and mechanical properties, which make it an appropriate
choice for promoting epidermal cell migration on the surfaces of percutaneous implants. We deposited a ~150 nm thick UNCD
film on a microporous silicon nitride membrane using microwave plasma chemical vapor deposition. Scanning electron microscopy
and Raman spectroscopy were used to examine the pore structure and chemical bonding of this material, respectively. Growth
of human epidermal keratinocytes on UNCD-coated microporous silicon nitride membranes and uncoated microporous silicon nitride
membranes was compared using the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay. The results show
that the UNCD coating did not significantly alter the viability of human epidermal keratinocytes, indicating potential use
of this material for improving skin sealing around percutaneous implants. |
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