| 微波催化合成N-(2-吡啶基)邻苯二甲酰亚胺的研究 |
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| 引用本文： | 陈平,张士娥,黄朋勉,颜少慰,辛玉兵,李锦锦. 微波催化合成N-(2-吡啶基)邻苯二甲酰亚胺的研究[J]. 精细化工中间体, 2008, 38(6) |
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| 作者姓名： | 陈平 张士娥 黄朋勉 颜少慰 辛玉兵 李锦锦 |
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| 作者单位： | 长沙理工大学,化学与生物工程学院,湖南,长沙,410076;山东省医学科学研究院,山东,济南,250062 |
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| 基金项目： | 湖南省教育厅资助项目 |
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| 摘 要： | 用微波催化法制备N-(2-吡啶基)邻苯二甲酰亚胺,考察了功率、时间、反应物料配比,溶剂等参数,得到优化工艺参数为:以N,N-二甲基甲酰胺为溶剂:功率5.0W,物料比n(2-氨基吡啶)∶n(邻苯二甲酸酐)=1∶1.2,反应时间6min,收率91.3%;无溶剂时:功率5.0W,物料比n(2-氨基吡啶)∶n(邻苯二甲酸酐)=1∶1.2,反应时间8min,收率:85.5%。微波催化法具有环保、时间短、收率高、后处理简单等优势。
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| 关 键 词： | N-(2-吡啶基)邻苯二甲酰亚胺 微波催化 合成 |
Microwave Catalytic Synthesis of 2-(Pyridin-2-yl)isoindoline-1,3-dione |
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| CHEN Ping,ZHANG Shi-e,HUANG Peng-mian,YAN Shao-wei,XIN Yu-bing,LI Jin-jin. Microwave Catalytic Synthesis of 2-(Pyridin-2-yl)isoindoline-1,3-dione[J]. Fine Chemical Intermediates, 2008, 38(6) |
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| Authors: | CHEN Ping ZHANG Shi-e HUANG Peng-mian YAN Shao-wei XIN Yu-bing LI Jin-jin |
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| Affiliation: | CHEN Ping1,ZHANG Shi-e2,HUANG Peng-mian1,YAN Shao-wei1,XIN Yu-bing1,LI Jin-jin1 ( 1. College of Chemical , Biological Engineering,Changsha University of Science , Technology,Changsha 410076,China,2. Sh,ong Academy of Medical Sciences,Jinan 250062,China) |
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| Abstract: | 2 -(Pyridin -2 -yl)isoindoline -1,3 -dione was prepared with microwave technology, and the optimal parameters such as power, reactive time and ratio of reaction material were obtained. In the DMF solvent, yield of the product was 91.3% under the optimal conditions of power 5.0 w, ratio 1∶1.2 and reaction time 6 min. In no solvent, the yield of the product was 87.4% under the conditions such as power 5.0 w, ratio 1∶1.2 and reation time 8 min. By contrast, the microwave catalytic technology had the advantages over the environmental compatability, short time, high yield and simple post-treatment. |
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| Keywords: | 2-(pyridin-2-yl)isoindoline-1 3-dione microwave catalytic synthesis |
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