| 蛋白质药品冷冻干燥技术研究进展 |
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| 引用本文： | 陈光明.蛋白质药品冷冻干燥技术研究进展[J].制冷空调与电力机械,2003,24(2):1-7. |
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| 作者姓名： | 陈光明 |
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| 作者单位： | 浙江大学,制冷与低温研究所,杭州,310027 |
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| 摘 要： | 冷冻干燥技术是制备固体蛋白质药品的常用方法。本文综述了蛋白质药品冻干保护机理、冻干工艺、冻干机的研究进展，并提出了优化药品冷冻干燥过程，提高药品的稳定性和经济性的研究思路。
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| 关 键 词： | 蛋白质药品 冷冻 干燥 稳定性 经济性 生物制品 脱水 |
| 文章编号： | 1006-8449(2003)02-0001-07 |
| 修稿时间： | 2003年2月26日 |
Development of Protein Pharmaceuticals Lyophilization |
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| CHENGuang-ming.Development of Protein Pharmaceuticals Lyophilization[J].Refrigeration Air Conditioning & Electric Power Machinery,2003,24(2):1-7. |
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| Authors: | CHENGuang-ming |
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| Abstract: | Lyophilization(freeze-drying) is the most commonly used method for preparing solid protein pharmaceuticals.This article reviews the recent developments in three areas, the mechanism of lyo-protection, the lyophilization progressof protein pharmaceuticals and the lyophilizer. It is pointed out that the further study in this field is to optimize thelyophilization cycle , improve the quality of protein pharmaceuticals and decrease the initial cost. |
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| Keywords: | lyophilization protein pharmaceuticals research review |
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