| TiO_2/SO_4~(2-)型固体酸催化合成丙酮缩二甲醇 |
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| 引用本文： | 杨淑敏,王海民,吕剑,刘鸿.TiO_2/SO_4~(2-)型固体酸催化合成丙酮缩二甲醇[J].精细化工中间体,2001,31(5):26-27,29. |
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| 作者姓名： | 杨淑敏 王海民 吕剑 刘鸿 |
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| 作者单位： | 西安近代化学研究所医药开发部,陕西,西安,710065 |
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| 摘 要： | 原甲酸三甲酯和丙酮在TiO2 /SO4 2 - 型固体酸的催化作用下合成了丙酮缩二甲醇 ,并对诸影响因素进行了考察。在反应温度 0～ 5℃ ,反应时间 1h ,原料配比原甲酸三甲酯∶丙酮∶催化剂 (m /m) =10 6∶5 8∶4的优惠工艺条件下 ,此反应可定量完成 ,精馏分离后收率94 .2 % ,纯度 98.1%。催化剂可重复使用多次。用红外、核磁验证了产物结构
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| 关 键 词： | 丙酮缩二甲醇 TiO2/SO42-固体酸 合成 |
| 文章编号： | 1009-9212(2001)05-0026-02 |
Catalytic Synthesis of Acetone Dimehtyl Ketal with TiO2/SO42- Solid Acid |
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| YANG Shu min,WANG Hai min,LU Jian,LIU Hong.Catalytic Synthesis of Acetone Dimehtyl Ketal with TiO2/SO42- Solid Acid[J].Fine Chemical Intermediates,2001,31(5):26-27,29. |
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| Authors: | YANG Shu min WANG Hai min LU Jian LIU Hong |
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| Abstract: | Acetone dimethyl acetal was synthesized from trimethyl orthoformate and acetone, the reaction was characterized by the catalysis of TiO 2/SO 4 2- solid acid and quantitative conversion. The influence factors were investigated, the results showed that the optimum conditions were as follows: reaction temperature 0～5℃, reaction time 1h, m(trimethyl orthoformate)∶m(acetone)∶m(solid acid)=106∶58∶4. The solid acid can be used repeatedly. The yield was 94.2% after rectification and the purity was 98.1%. The structure of the product was identified with IR and 1HNMR |
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| Keywords: | acetone dimethyl acetal TiO 2/SO 4 2- solid acid synthesis |
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