Distribution and residue depletion of oxytetracycline in giant freshwater prawn (Macrobrachium rosenbergii) |
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Authors: | Poapolathep Amnart Poapolathep Saranya Imsilp Kanjana Wannapat Nutthapong Klangkaew Narumol Kusutjarit Napasorn Kumagai Susumu |
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Affiliation: | Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900 Thailand. fvetamp@hotmail.com |
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Abstract: | Distribution and residue depletion patterns of oxytetracycline were examined in giant freshwater prawns, Macrobrachium rosenbergii, after medicated-feed treatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The concentration of oxytetracycline in prawn muscle tissues was measured using high-performance liquid chromatography equipped with a fluorescence detector. The limit of detection was 0.1 microg/g. In the medicated-feed-treated group, oxytetracycline was detectable 8 days posttreatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The depletion half-life and mean residence time of oxytetracycline were 30.96 and 100.3 h, respectively. The dose of 4 g/kg of feed for 5 consecutive days can be recommended for therapeutic dosage regimen in giant freshwater prawn aquaculture. The minimal withdrawal period of M. rosenbergii muscle tissue should be 8 days postcessation of medicated feed. |
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