| 金属催化重氮化合物参与的分子间多组分反应研究进展 |
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| 引用本文： | 李志成,杜瑞华,胡文浩.金属催化重氮化合物参与的分子间多组分反应研究进展[J].广东化工,2007,34(6):70-74,96. |
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| 作者姓名： | 李志成 杜瑞华 胡文浩 |
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| 作者单位： | 1. 河南工业大学,化学化工学院,河南,郑州,450052
2. 华东师范大学,化学系,上海,200062 |
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| 基金项目： | 国家自然科学基金
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河南工业大学校科研和教改项目 |
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| 摘 要： | 本文根据反应历程综述了金属催化重氮化合物参与的分子间MCR的研究进展,经羰基叶立德和亚胺叶立德中间体的1,3-偶极环加成反应是构建四氢呋喃环、1,3-二氧五环、四氢吡咯环等含氧、氮的五元杂环结构的有效方法,具有反应产率高、立体选择性好等特点;经1,2-偶极结构的铵基叶立德和氧鎓叶立德中间体的亲核加成反应能够一步合成重要的有机中间体.
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| 关 键 词： | MCR 金属催化 重氮化合物 1 3-偶极环加成反应 铵基叶立德 氧鎓叶立德 |
| 修稿时间： | 2007-02-10 |
Research Progress on the Metal-catalyzed Multicomponent Reactions of Diazo Compounds |
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| Li Zhicheng,Du Ruihua,Hu Wenhao.Research Progress on the Metal-catalyzed Multicomponent Reactions of Diazo Compounds[J].Guangdong Chemical Industry,2007,34(6):70-74,96. |
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| Authors: | Li Zhicheng Du Ruihua Hu Wenhao |
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| Affiliation: | 1.School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450052; 2. Department of Chemistry, East China Normal University, Shanghai 200062, China |
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| Abstract: | The recent research progress on the metal-catalyzed intermolecular multicomponent reactions of diazo compounds was reviewed according to the reaction pathway in this paper. The 1,3-dipolar cycloaddition of carbonyl ylide and imine ylide was an efficient method for construction of five-membered heterocycles containing oxygen or nitrogen atom such as tetrahydro-furan, 1,3-dioxolanes or pyrrolidines in high yield with excellent stereoselectivity. The some important intermediates could be synthesized one-step by the nucleophilic addition of ammonium ylide and oxonium ylide. |
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| Keywords: | multicomponent reaction metal-catalyzed diazo compounds 1 3-dipolar cycloaddition ammonium ylide oxonium ylide |
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