|
|||||
|
|
Improved infrared spectroscopic method for the analysis of degree of N-deacetylation of chitosan |
|
| Authors: | Shobhan Sabnis Lawrence H. Block |
| Affiliation: | (1) Research and Technology, Block Drug Company, Inc., 257 Cornelison Avenue, Jersey City, NJ 07302, USA, US;(2) Department of Medicinal Chemistry and Pharmaceutics, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA, US |
| Abstract: | Various infrared spectroscopic techniques for the analysis of degree of N-deacetylation of chitosan were evaluated for accuracy. A new method was proposed which involved development of a calibration curve using the absorbance intensities of the chitosan infrared spectrum at 1655 and 3450 cm−1. The degree of N-deacetylation of various chitosan samples was then determined by using the absorption ratios [A1655/A3450] in the equation of the calibration curve. This method yielded results which were superior to those of any of the previously reported infrared spectroscopic methods tested herein. Received: 27 March 1997/Revised: 16 May 1997/Accepted: 22 May 1997 |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |