| 2-正丁基-4-氯-5-甲酰基咪唑合成新工艺 |
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| 引用本文： | 蒋军荣,徐峰,柯中炉,陈红云,刘学峰.2-正丁基-4-氯-5-甲酰基咪唑合成新工艺[J].山东化工,2013(11):5-6,11. |
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| 作者姓名： | 蒋军荣 徐峰 柯中炉 陈红云 刘学峰 |
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| 作者单位： | 台州职业技术学院生化制药研发中心,浙江台州318000 |
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| 基金项目： | 2012年度台州市科技计划项目（1202ky11） |
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| 摘 要： | 以戊腈为原料，经加成、取代得到脒（2），再与乙二醛缩合、脱一分子水得到眯唑啉酮化合物（3），最后经氯代、氧化后得到2-正丁基-4-氯-5-甲酰基咪唑，收章40．5％。该工艺具有原料易得，反应条件温和，合成路线短，易于工业化生产等特点，是-条新的2-正丁基-4-氯-5-甲酰基咪唑（1）合成路线。
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| 关 键 词： | 戊脒 乙二醛 2-正丁基-4-氯-5-甲酰基咪唑 |
Novel Syntheses of 2 - Butyl - 5 - chloro - 1H - imidazole - 4 - carboxaldehyde |
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| Affiliation: | JIANG Jun - rong ,XU Feng ,KE Zhong - lu, CHEN Hong - yun ,LIU Xue -feng (R＆D Centre of Biochemistry Pharmacy, Taizhou Vocational ＆ Technical College,Taizhou 318000, China) |
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| Abstract: | 2 - Butyl - 5 - chloro - 1 H - imidazole - 4 - carboxaldehyde was synthesized from valeronitrile by addition with CH3OH/HC1, substitution to afford pentanimidamide hydrochloride,which subsequently subjected to condensation with aqueous solution of glyoxal, dehydration to give 2 - butyl - 1H - imidazol -4（5H） -one, which was subjected to chlorination and then oxidation in yield of 40.5%. The route was new route to synthesis of 2 - butyl - 5 - chloro - 1H - imidazole - 4 - carboxaldehyde, which has some advantages such as availability of raw materials, mild reaction condition, short synthesized route, good yields, and suitable for industrial- scale production. |
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| Keywords: | pentanimidamide glyoxal 2 - butyl - 5 - chloro - 1H - imidazole - 4 - carboxaldehyde |
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