Synthesis and characterization of pH- and thermoresponsive Poly(<Emphasis Type="Italic">N</Emphasis>-isopropylacrylamide-co-itaconic acid) hydrogels crosslinked with <Emphasis Type="Italic">N</Emphasis>-maleyl chitosan |
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Authors: | Yueqin Yu Yanshun Li Lingxiu Liu Chunjing Zhu Yang Xu |
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Affiliation: | (1) Key Laboratory of Eco-chemical Engineering, Ministry of Education; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People’s Republic of China |
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Abstract: | Biodegradable cross-linker N-maleyl chitosan (N-MACH) was synthesized with chitosan (CS) and maleic anhydride (MA) by acylation. With N-MACH cross-linker, a series of cross-linked poly(N-isopropylacrylamide-co-itaconic acid) P(NIPAAm-co-IA)] hydrogels were prepared, and their pH-and temperature-responsive
behaviors, water contents, swelling/deswelling kinetics were investigated. By alternating the NIPAAm/IA weight ratios, hydrogels
had the volume phase transition temperature (VPTT) changed from 33 to 38 °C, whereas cross-linking density did not affect
the VPTT apparently. The water content of hydrogels was controlled by the monomer weight ratios of NIPAAm/IA, swelling media,
and the cross-linking density. The results of the influence of pH value on the swelling behaviors showed that the minimum
swelling ratios of the hydrogels appeared in neutral buffer solution, which was attributed to chemical composition of the
hydrogels and the swelling media. In the swelling/deswelling kinetics, all the dried hydrogels exhibited fast swelling within
480 min and fast deswelling within 20 min, which was independent of the content of IA and cross-linker. |
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