Persistent short term memory deficits in Hebb–Williams maze performance are shown by rats with unilateral entorhinal cortex lesions.

The spatial abilities of adult, male Sprague-Dawley rats in the Hebb–Williams maze were examined at 6 mo after unilateral electrolytic entorhinal cortex lesions. Compared with sham-operated rats, their performance was impaired in both initial entry and repeat entry errors over 12 consecutive problems, using immediate starting replacement for the 6 trials per problem. The configurations of the 12 maze problems are independent, and deficits were seen over the entire course of the testing. This study indicates that Hebb–Williams maze performance deficits after unilateral entorhinal cortex lesion are persistent and can be seen up to 6 mo after injury. (PsycINFO Database Record (c) 2010 APA, all rights reserved)