Polyphenol-rich longan (Dimocarpus longan Lour.)-flower-water-extract attenuates nonalcoholic fatty liver via decreasing lipid peroxidation and downregulating matrix metalloproteinases-2 and -9 |
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| Authors: | Cheng-Wei Liu Deng-Jye Yang Yuan-Yen Chang Chin-Lin Hsu Jung-Kai Tseng Ming-Hsu Chang Meiling Wang Yi-Chen Chen |
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| Affiliation: | 1. Department of Post-Modern Agriculture & Department of Biotechnology, MingDao University, ChangHua 523, Taiwan;2. School of Health Diet and Industry Management, Chung Shan Medical University, Taichung 402, Taiwan;3. Department of Microbiology and Immunology, School of Medicine & Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan;4. School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan;5. School of Optometry, Chung Shan Medical University, Taichung 402, Taiwan;6. Department of Baking Technology and Management, National Kaohsiung University of Hospitality and Tourism, Kaohsiung 812, Taiwan;7. Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan |
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| Abstract: | Longan-flower-water-extract (LFWE) contains large amounts of phytochemicals where gentisic acid and epicatechin are the major compounds in phenolic acid and flavonoid compound, respectively. The objective of this study was to investigate if drinking LFWE could protect the liver from a hypercaloric dietary habit. Only rats fed the hypercaloric diet (HCD) with 25 g/L (w/v) LFWE solution (HCD_2X) group demonstrated lower (p < 0.05) serum triglyceride levels compared to those fed the HCD with normal distilled water (HCD_NDW) and HCD with 12.5 g/L (w/v) LFWE solution (HCD_1X) groups. However, drinking LFWEs decreased (p < 0.05) hepatic lipids in the HCD rats. Lower (p < 0.05) hepatic MDA levels, GOT and GPT values, and higher (p < 0.05) hepatic GSH levels were observed in HCD rats drinking LFWE. Besides, drinking LFWE downregulated (p < 0.05) gene expressions and activities of hepatic matrix metalloproteinases-2 and -9 (MMP-2/9) in HCD rats. In conclusion, polyphenol-rich LFWE displayed hepatoprotective characteristics against an energy-dense dietary habit. |
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