氧化石墨烯/丙酸氯倍他索分子捕获器的制备及性能

以氧化石墨烯修饰聚乙烯滤板为内部支撑体,采用表面分子印迹技术,以丙酸氯倍他索为模板分子,3-氨丙基三乙氧基硅烷为功能单体,正硅酸乙酯为交联剂,在内部支撑体表面进行分子印迹,制备了一种对丙酸氯倍他索具有特异选择吸附能力的分子捕获器。分别采用FTIR、FESEM、EDS、TGA对分子捕获器的结构、形貌、热稳定性进行了表征。并对其吸附性能进行了研究,结果表明,该分子捕获器对丙酸氯倍他索具有较好的结合性能。将该分子捕获器作为固相萃取整体材料,结合高效液相色谱检测,应用于加标化妆品样品中丙酸氯倍他索的选择性富集分离,方法检出限为0.04 mg/L,准确性、精密度良好。分子捕获器可以重复使用4次,具有良好的耐用性。

Preparation and Properties of Clobetasol Propionate/Molecular Capture Based on Graphene Oxide

A solid phase extraction material with specificity extracting clobetasol propionate of molecular capture was prepared by surface imprinting technique in combination with based on solid phase extraction column sieve plate coated with graphene oxide. The molecular capture(MC) was prepared by using clobetasol propionate as template molecule, 3-Aminopropyltriethoxysilane as monomer and ethyl silicate as cross-linker, respectively. The morphology and structure of the molecular-catcher was characterized by FTIR, FESEM, EDS and TGA. The molecular capture was studied by the re-binding experiments, such as adsorption kinetics, adsorption isotherm, molecular identification, applied to the separation and enrichment of clobetasol propionate in cosmetic. The results showed that the molecular capture has a fast adsorption equilibrium, highly improved imprinting capacity and significant selectivity; the detection limit was 0.04 mg/L (S/N=3). The durability test showed that the MC could be reused more than 4 times by re-binding experiments.