| 凉味剂左旋薄荷酰胺的合成 |
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| 引用本文： | 王建新,聂侃,罗玲玲.凉味剂左旋薄荷酰胺的合成[J].香料香精化妆品,2004(4):5-6,10. |
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| 作者姓名： | 王建新 聂侃 罗玲玲 |
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| 作者单位： | 江南大学化工学院 无锡214036
(王建新，聂侃)，江南大学化工学院 无锡214036(罗玲玲) |
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| 摘 要： | 凉味剂WS 3 (即N 乙基 L 薄荷基甲酰胺 )可以左旋薄荷醇为原料 ,经氯代、羧酸化和酰胺化三步制成 ,以左旋薄荷醇为起始原料计 ,总产率为 3 0 .1 %。中间体 ( 1R ,2S ,5R) ( ) 氯代薄荷、( 1R ,2S ,5R) ( ) 薄荷基羧酸、( 1R ,2S ,5R) ( ) 薄荷基羧酸酰氯和终产品N 乙基 L 薄荷基甲酰胺通过GC、m .p.、旋光度的测定及红外光谱等分析确证其与目标产物结构一致。左旋的凉味剂WS 3凉味纯正强烈 ,无杂味。
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| 关 键 词： | 凉味剂 薄荷酰胺 合成 |
The Synthesis of Cooling Agent Optical Rotation N-ethyl-L-menthylformylamine |
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| Wang Jianxin,Nie Kan,Luo Linlin.The Synthesis of Cooling Agent Optical Rotation N-ethyl-L-menthylformylamine[J].Flavour Fragrance Cosmetics,2004(4):5-6,10. |
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| Authors: | Wang Jianxin Nie Kan Luo Linlin |
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| Abstract: | The cooling agent WS-3(N-ethyl-L-menthylformylamine ) was prepared from (1R,2S,5R) -(-)-menthol as starting material through chlorination, carboxylation and amidization three steps. The total yield was 30.1% according to menthol. The intermediates (1R,2S,5R)-(-)-menthyl chloride, (1R,2S,5R)-(-)- menthyl carboxylic acid and the end-product were detected by GC, IR , m.p.,optical rotation and so on. The synthesized product was pure and had strong cooling taste. |
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| Keywords: | Cooling agent N-ethyl-L-menthylformylamine Synthesis |
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