| β-环糊精-毛细管区带电泳分离扑尔敏对映体 |
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| 引用本文： | 李方,靳慧,顾峻岭,傅若农.β-环糊精-毛细管区带电泳分离扑尔敏对映体[J].北京理工大学学报(英文版),1997,6(1):52-58. |
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| 作者姓名： | 李方 靳慧 顾峻岭 傅若农 |
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| 作者单位： | 北京理工大学化工与材料学院,北京 100081;北京理工大学化工与材料学院,北京 100081;北京理工大学化工与材料学院,北京 100081;北京理工大学化工与材料学院,北京 100081 |
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| 摘 要： | 采用毛细管区带电泳模式,以β-环糊精为手性选择剂分离了药物扑尔敏的光学对映体.考察了在不同背景电解质 pH 值尤其是较低 pH 值下环糊精浓度对对映体表观淌度差的影响,并研究了有机改性剂尿素在分离中的作用.
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| 关 键 词： | 毛细管区带电泳 手性分离 对映体 环糊精 |
Study on Capillary Zone Electrophoretic Separation of Chlorpheniramine Enantiomers with β-Cyclodextrin |
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| Li Fang,Jin Hui,Gu Junling and Fu Ruonong.Study on Capillary Zone Electrophoretic Separation of Chlorpheniramine Enantiomers with β-Cyclodextrin[J].Journal of Beijing Institute of Technology,1997,6(1):52-58. |
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| Authors: | Li Fang Jin Hui Gu Junling and Fu Ruonong |
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| Affiliation: | School of Chemical Engineering and Materials Science,Beijing Institute of Technology,Beijing 100081;School of Chemical Engineering and Materials Science,Beijing Institute of Technology,Beijing 100081;School of Chemical Engineering and Materials Science,Beijing Institute of Technology,Beijing 100081;School of Chemical Engineering and Materials Science,Beijing Institute of Technology,Beijing 100081 |
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| Abstract: | The chlorpheniramine enantiomers were separated with capillary zone electrophoresis using β-cyclodextrin as the chiral selector.The effects of the concentration of β-cyclodextrin, the electrolyte pH and organic modifier(urea) on the difference in apparent electrophoretic mobilities of the enantiomels were investigated. |
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| Keywords: | , , , |
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