| 西他列汀侧链哌嗪盐酸盐制备的工艺优化 |
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| 引用本文： | 唐红,贺银翠,张义长.西他列汀侧链哌嗪盐酸盐制备的工艺优化[J].云南化工,2019(7). |
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| 作者姓名： | 唐红 贺银翠 张义长 |
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| 作者单位： | 铜仁学院材料与化学工程学院 |
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| 摘 要： | 为了提高西他列汀侧链哌嗪盐酸盐的产率,并简化操作,以三氟乙酸乙酯为原料,经肼解、氧氯化磷环合、乙二胺亲核取代、闭环等反应,制备了3-(三氟甲基)-5,6,7,8-四氢1,2,4]三唑并4,3-α]哌嗪盐酸盐。工艺产物收率较高,反应条件温和,操作简单,溶剂回收简单。
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| 关 键 词： | 3-（三氟甲基）-5 6 7 8-四氢[1 2 4]三唑并[4 3-α]哌嗪盐酸盐 西他列汀侧链哌嗪盐酸盐 工艺优化 |
Process optimization of sitagliptin side chain piperazine hydrochloride preparation |
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| Affiliation: | ,College of Material and Chemical Engineering of Tongren University |
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| Abstract: | In order to improve the yield of side chain piperazine hydrochloride of statin and simplify the operation. In this study, 3-(trifluoromethyl)-5,6,7,8-tetrahydro 1,2,4] triazolo 4,3-a] piperazine hydrochloride was prepared from ethyl trifluoroacetate by hydrazinolysis, cyclization of phosphorus oxychloride, nucleophilic substitution of ethylenediamine and closed-loop reaction. The process has the advantages of high yield, mild reaction conditions, simple operation and simple solvent recovery. |
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| Keywords: | 3-(trifluoromethyl)-5 6 7 8-tetrahydro [1 2 4] triazole [4 3-α] piperazine hydrochloride Sitagliptin side chain piperazine hydrochloride Process optimization |
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