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Bioactive polymers LVII. A novel drug delivery system based on 5-nitro-2-furaldehyde-semicarbazone and poly(acrylic acid-co-vinyl alcohol) |
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| Authors: | Severian Dumitriu Marcel Popa Simion Petrovan Raluca Staicu |
| Abstract: | The coupling of 5-nitro-2-furaldehyde-semicarbazone on to poly(acrylic acid-co-vinyl alcohol) copolymer by the use of dicyclohexylcarbodiimide as activator has been studied. On the basis of an experimental design, the influence of different parameters is studied (activator/support, drug/support, reaction time, solvent volume) in order to determine the optimum conditions for obtaining the maximum amount of the coupled drug on the support. |
| Keywords: | retardation Nitrofuran® macromolecular drug bioactive polymers dicyclohexylcarbodiimide (DCI) |