缩宫素对超声消融治疗子宫腺肌症的量效关系研究

目的：评价不同缩宫素剂量对超声消融子宫腺肌症的影响以及缩宫素在超声消融治疗过程中使用的安全性。方法：129例确诊的子宫腺肌症患者随机分为对照组、缩宫素0．32U／min组、缩宫素0．48U／min组进行超声消融治疗，比较各组间的消融效果及相关不良反应。结果缩宫素0．32U／min组和0．48U／min组分别与对照组相比，病灶体积消融率均明显高于对照组，消融单位体积所需时间和能效因子均明显小于对照组，差异有统计学意义。缩宫素0．32U／min组和0．48U／min组相比较，病灶体积消融率、消融单位体积所需时间和能效因子无显著性差异。三组均无严重不良反应。结论缩宫素能安全有效地降低超声消融子宫腺肌症所需的能量，提高治疗效率，但是增大剂量并不能提高超声消融的效益。

Dose- effect research on the effect of Oxytocin on high intensity focused ultrasound ablation of adenomysis

Objective： To explore the effects and safety of different close of oxytocin on high intensity focused ultrasound （HIFU） ablation of adenomysis. Methods 129 patients with adenomyosis from three hospitals were treated with ultrasound - guided HIFU. The patients were randomly assigned in 0.32U /rain oxytocin group ,0.48U/min oxytocin group , or control granp. To compare energy, sonication time required to ablate 1 era3 of adenomyosis, side- effects between three groups. Results The non - perfused volume （NPV） ratio of the two groups with using oxytocin are significantly higher than without one. The sonication time required to ablate lcm3 and EEF are below. There are no significantly difference in NPV ratio, EEF, sonieation time required to ablatelcm3 between the two groups with oxytocin. Conclusion Oxytocin could significantly decrease the energy for ablating adonomysis with HIFU, enhance the treatment efficiency. It can not increase benefit to increase the doses of Oxytocin.