Automatic Synthesis of 18F-6-F-L-DOPA and its Application in Clinical PET Imaging |
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Authors: | FU Huaping ZHANG Xiaojun MA Guangyu LIU Jian XU Xiaodan XU Baixuan ZHANG Jinming |
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Affiliation: | Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing 100853,China |
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Abstract: | 18F-6-Fluoride-L-DOPA (18F-DOPA) has an important value in the imaging diagnosis of neuroendocrine tumors. In this study, we used homemade Fluoride-module to synthesis18F-DOPA and evaluate its clinical imaging.18F-DOPA was synthesized by direct nucleophilic reaction with 6-boric acid-dimethoxy-L-DOPA as precursor, Cu(OTf)2(py)4 as catalyst, and hydrolysis by hydriodic acid. Quality control and the in vitro stability were preformed. The18F-DOPA was confirmed PET imaging of neuroendocrine neoplasms and control. It took 60 minutes from 18F ions to 18F-DOPA, no corrected efficiency was (10.0±2.3)% (n=6), radiochemistry purity was over 99%. It could got 7.4 GBq of18F-DOPA once time. The trace of ascorbic acid or ethanol could prevent radiolysis of 18F-DOPA. The striatum was seen at18F DOPA imaging. The radioactivity were mainly extracted through kidney and urine. A positive lesion in pancreatic in patient with neuroendocrine tumor.18F-DOPA was synthesized by direct nucleophilic reaction with homemade Fluoride-module. It could got good repeatability and high quality for clinical used. |
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Keywords: | 18F-6-Fluoride-L-DOPA 6-boric acid-dimethoxy-DOPA Cu(OTf)2(py)4 neuroendocrine neoplasm |
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