复方分子探针及其显像

为克服［¹⁸F］FDG PET、联合用分子探针显像和多靶向偶合分子探针显像的局限性，本文首次提出“复方分子探针及其显像”概念模式。复方分子探针制备方法包括分次合成配制法、一锅单次合成法和同时平行合成法，其中一锅单次合成法最为简便实用，较有前景。复方分子探针具有固定配比、可单次生产配制、药效稳定可控，以及改善用药依从性和使用方便等优势。复方分子探针的研发间接解决了多靶向偶合分子探针复杂合成方面的难题，为创制下一代新型分子探针提供了简单、实用和易推广新模式。复方分子探针显像解决了多模式分子探针同时显像的重要科学问题，为进一步开展复方多模式分子探针显像奠定了基础。联合双探针单次给药同时显像、联合双探针双模式显像和术中联合多探针显像导向治疗，在精准医学方面显示巨大应用潜力，为进一步发展和转化应用复方分子探针显像奠定了基础。本文对“复方分子探针及其显像”的理论依据、概念和原理、重要性、制备方法及其潜在应用价值进行了阐述。

Compound Molecular Probe and Imaging

To overcome limitations of 2-［¹⁸F］fluorodeoxy-D-glucose (［¹⁸F］FDG) positron emission tomography (PET) imaging, molecular probes combination imaging and multi-targeting coupling molecular imaging, concept and modality of “fixed -dose compound molecular probe and imaging” are first proposed. Synthetic method of compound molecular probe includes multiply-synthesis preparation, one-pot single synthesis and simultaneous parallel synthesis. Among them, one-pot single synthesis is most simple and practical method with good prospect. Compared with combined molecular probes, compound molecular probes are innovative fixed-dose combination molecular probes, with advantages of fixed ratio, one-pot single synthestic preparation, stable and controllable drug effect, improved medication compliance, and convenient to use. Research and development of compound molecular probes have indirectly solved the complicated problems of the preparation of multi-target coupling molecular probes and provided a simple, practical and easy to popularize new mode for the next generation of new molecular probes. Compound molecular probe imaging has cleverly resolved the important scientific issues of simultaneous imaging of multi-modality molecular probes and laid a foundation for further development of compound multi-modallity molecular probe imaging. Combined double probes single-dose simultaneous imaging, combined double probes dual-modality imaging and intraoperative combined multi-probe imaging-guiding therapy have huge potential application in precision medicine and lay a foundation for further development and transformation application of compound molecular probe imaging. This review summarizes theory evidence, concept and principle, importance, main research contents, and potential application of compound molecular probe and imaging. Also, preparation of compound molecular probe is discussed.