以对羟基苯甲醛和乙酰丙酮合成双去甲氧基姜黄素的合成研究

从双去甲氧基姜黄素的合成着手,以对羟基苯甲醛和乙酰丙酮为原料,经过亲电反应、萃取分离、重结晶等一系列的有机反应和分离步骤,最终得到双去甲氧基姜黄素.实验过程中,用TLC点板检测反应进度;最终得到的产品用熔点法检测其熔点,HPLC检测其纯度.结果表明,产品即为双去甲氧基姜黄素,纯度为99％.探讨了反应温度、药品使用量对最终收率的影响.合成成本低,产率高,不需要使用有毒药品和昂贵精密的大型仪器,适合工业化大生产.

The Synthesis of Bisdemethoxycurcumin by Hydroxy Benzaldehyde and Acetyl Acetone

This paper goes at the synthesis of bisdemethoxycurcumin, to the hydroxy benzaldehyde and acetyl acetone as raw materials, after electrophilic reaction, extraction separation, recrystallization and a series of organic reactions and separation steps, eventually bisdemethoxycurcumin could be got. During the experiment ,TLC is used to detect the reaction progress; melting point method is used to detect the melting point and the purity is detected by HPLC . The results show that product is bisdemethoxycurcumin with the purity of 99%. This paper also discusses the reaction temperature, drug usage, influencing on the final yield . The method has advantages over low cost, high production, and without toxic drugs and expensive large precision instruments, it is suitable for industrialized production.