丹参提取物耐缺氧功能及营养化学研究

目的：探讨丹参提取物对小鼠耐常压缺氧功能及其功能营养化学基础。方法：用常压缺氧小鼠模型试验研究提取物耐缺氧活性，对提取物中功能成分和营养素进行测定和比较。结果：丹参提取物能显著延长小鼠耐常压缺氧的存活时间。提取物中含有丰富的耐缺氧功能因了和相关性营养成分，其中，醇提物中丹参酮IIA1.43％、隐丹参酮0．51％、丹参酮10．1％、丹参素2．14％、原儿茶醛0．33％、多糖含量4．6％。每100g提取物中VC、VE和胡萝卜素的含量分别为0．722mg、25．9mg和0．47mg。结论：丹参提取物具有增强模型小鼠耐常压缺氧能力，其中耐缺氧功能因了和相关性营养素含量丰富。提示这些成分是其耐缺氧作用的物质基础。丹参提取物作为功能食品基料具有良好的应用基础。

Study on the Anti-hypoxia Activity and Nutrition Chemistry of Danshen Extract in Mice

Objective:To study on the anti-hypoxia function and nutrition chemistry in Danshen extract. Method: To use mice to test on anti-hypoxia activity of danshen extract and the active components to be determined by HPLC combined with chemical standard materials. Nutritional elements were also assayed with different procedure according to their characteristics. The bioactive results were compared to functional and nutritional components. Results: It showed that the Danshen extract could prolong the serving time of testing rats. The functional and nutritional components of anti-hypoxia function were rich in the extract. 5 kinds of active components were separated as tanshinoneIIA1.43%, crytotanshinone 0.51%, tanshinoneI 0.1%, 3,4- Dihydroxyphenyllactic acid 2.14%, protocatechuic aldehyde 0.33%, polysaccharide 4.6% in alcohol extract. The contents of vitamin C, E and carotene were 0.722 mg, 25.9 mg and 0.47 mg, respectively. Conclusions: Danshen extract had the function role of anti-hypoxia based on the functional and nutritional factors. It could be used as health improving additives.