超高分辨离子迁移谱技术及应用进展

近年来，随着大气压样品进样、离子源和离子操控等技术的发展，离子迁移谱已从化学战剂、爆炸物和毒品的专用检测技术迅速发展成为一种在分析领域广泛使用的技术。随着检测对象越来越复杂，对离子迁移谱的分析性能提出了更高要求，特别是对超高分辨能力的需求。本文首先介绍了超高分辨离子迁移谱的原理及技术进展，在此基础上，阐释其分辨能力的决定因素、优缺点等；然后，探讨其在生物分子构象分析中的应用及存在的问题；最后，展望了超高分辨离子迁移谱的未来发展趋势。

Development of Ultra-high Resolution Ion Mobility Spectrometry and Its Applications

Recently, along with the development of ambient pressure sample introduction methods, ionization sources and ion manipulation methods, ion mobility spectrometry (IMS) has evolved from a specific use technology for detecting chemical warfare agents, explosives and drugs to a widely used technology for analytical and bioanalytical measurements. As increasing of the measurement task complexity, IMS of high analytical performance, especially ultra-high resolution, is required. Firstly, the theory and application of IMS were introduced. Secondly, the resulting effects of experimental parameters on resolving power were explained and compared among the different IMS types. Thirdly, the application of ultra-high resolution IMS in the bioanalytical field and the accompanied limitations were discussed. Finally, a brief perspective on the future development of ultra-high resolution IMS was provided.