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Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia.
Authors:Gur   Raquel E.
Abstract:
Reports 2 experiments relating schizophrenia to functional brain asymmetry. In Exp I, 24 schizophrenics (mean age, 30.8 yrs) were compared to 24 matched controls (mean age, 37.3 yrs) on 2 tachistoscopic tasks (Syllable Test and Dot Location Test) designed to measure verbal and spatial information processing in the 2 hemispheres. Unlike the controls, the schizophrenics showed a right hemisphere superiority both on the verbal and on the spatial tests, indicating left hemisphere dysfunction in the initial processing of verbal information. In Exp II, lateral eye movements, as an index of contralateral hemispheric activation, were measured in a group of 24 paranoid schizophrenics (mean age, 28.9 yrs), 24 nonparanoid schizophrenics (mean age, 32.7 yrs), and 24 matched controls (mean age, 31.2 yrs). The eye movements were elicited by presenting the Ss with verbal neutral, verbal emotional, spatial neutral, and spatial emotional questions. The schizophrenics had significantly more rightward eye movement, compared to controls, regardless of question type, indicating left hemisphere overactivation. Results suggest that schizophrenia is associated with a pattern consisting of both left hemisphere dysfunction and overactivation. (63 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)
Keywords:
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