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| Study on the preparation and biodistribution of ^99mTc-HMIBP | |
| 作者姓名： | GUO Xue-Hua LUO Shi-Neng * WANG Hong-Yong ZHOU Lian XIE Min-Hao YE Wan-Zhong YANG Min WANG Yang |
| 作者单位： | 1School of Chemical and Material Engineering，Southern Yangtze University，Wuxi 214036，China; 2Jiangsu Institute of Nuclear Medicine，Wuxi 214063，China |
| 摘 要： | |
| 关 键 词： | 骨显影剂 体内分解 ^99mTc 放射医学 |
| 收稿时间： | 08 10 2006 12:00AM |
Study on the preparation and biodistribution of Tc-HMIBP |
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| GUO Xue-Hua, LUO Shi-Neng,,* WANG Hong-Yong ZHOU Lian, XIE Min-Hao YE Wan-Zhong YANG Min WANG Yang.Study on the preparation and biodistribution of ^99mTc-HMIBP[J].Nuclear Science and Techniques,2006,17(5):285-288. | |
| Authors: | GUO Xue-Hua LUO Shi-Neng WANG Hong-Yong ZHOU Lian XIE Min-Hao YE Wan-Zhong YANG Min WANG Yang |
| Affiliation: | 1. School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China;Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China 2. Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China;School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China 3. Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China |
| Abstract: | 99mTc-HMIBP, a new bone-imaging agent, was prepared by the reduction of 99mTc-pertechnetate in the were more than 10 μg and 2.5 mg, respectively, the pH value was between 2 and 7, and the labeling reaction continued for 10 min, both labeling yield and radiochemical purity of 99mTc-HMIBP were more than 90%. The biodistribution in rats and bone scan in rabbits were also studied. The results showed that the bone uptake is up to 7.94%ID/g at 30 min after injection of 99mTc-HMIBP, bone-to-muscle and bone-to-blood uptake ratios were 20.89 and 16.89, respectively. The clear bone image was obtained at 120 min after injection of 99mTc-HMIBP and clearance in soft tissue was visible. All of the above-mentioned results suggested that 99mTc-HMIBP may be a potential bone-imaging agent. |
| Keywords: | Bone-imaging agent 99mTc-labeled HMIBP Biodistribution |
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