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| 6-氯哒嗪-3-羧酸甲酯的合成研究 | |
| 引用本文： | 赵春深,梁新霞,解海,金沧.6-氯哒嗪-3-羧酸甲酯的合成研究[J].广东化工,2011,38(3):71+74-71,74. |
| 作者姓名： | 赵春深 梁新霞 解海 金沧 |
| 作者单位： | 1. 贵州大学,化学与化工学院,贵州贵阳550003;贵州省发酵工程与生物制药重点实验室,贵州贵阳,550003 2. 贵州大学,化学与化工学院,贵州贵阳550003 3. 北京邮电大学信息光子学与光通信研究院,北,京,100876 |
| 摘 要： | 文章介绍了目标化合物6-氯哒嗪-3-羧酸甲酯方便的、高产率的合成方法.本方法以α-酮戊二酸,水合肼作为起始原料,经环合反应、与溴素反应、酯化反应、氯代反应4步,合成了目标化合物,并经IR和1HNMR等对其结构进行了表征.该合成路线原料易得,操作简便,且反应条件温和,适合工业化生产,反应总收率为64.8%. |
| 关 键 词： | α-酮戊二酸 中间体 药物合成 6-氯哒嗪-3-羧酸甲酯 |
Synthesis of Methyl 6-chloropyridazine-3-carboxylate |
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| Zhao Chunshen,Liang Xinxia,Xie Hai,Jin Cang.Synthesis of Methyl 6-chloropyridazine-3-carboxylate[J].Guangdong Chemical Industry,2011,38(3):71+74-71,74. | |
| Authors: | Zhao Chunshen Liang Xinxia Xie Hai Jin Cang |
| Affiliation: | 1.School of Chemistry and Chemical Engineering,Guizhou University,Guiyang 550003;2.Guizhou Province Key Laboratory of Fermentation Engineering and Biological Pharmacy,Guiyang 550003;3.Affiliated Zhongshan Hospital of Dalian University,Dalian 116001;4.Institue of Optical Communication and Optoelectronics,Beijing University of Posts and Telecommunications,Beijing 100876,China) |
| Abstract: | The paper introduced the synthesis of methyl 6-chloropyridazine-3-carboxylate which was convenient,high yield.To α-ketoglutarate as the starting material,reaction with the hydrazine hydrate,and bromine reaction,esterification,chlorination step 4 was synthesized target compounds.And its structure was verified by IR and 1HNMR.The synthetic material was easy,simple,and the reaction was mild.The total product yield was 64.8%. |
| Keywords: | α-ketoglutarate intermediate drug synthesis methyl 6-chloropyridazine-3-carboxylate |
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