鄂植8号、皮瓜尔油橄榄叶提取物对高血脂小鼠降血脂功效研究

研究探索了皮瓜尔油橄榄叶(Picual olive leaves,POL)和鄂植8号油橄榄叶(E planting No.8 olive leaves,EP8OL)提取物对高血脂症小鼠体重、肝损伤、血脂脂质水平的干预作用。通过高脂饮食建立高脂小鼠模型,以健康小鼠为空白组,模型小鼠分为对照组、橄榄叶提取物低剂量组、中剂量组、高剂量组,灌胃4周,测定各指标。实验结果显示,与对照组相比,油橄榄叶提取物给高脂小鼠灌胃28 d后,小鼠的肝脏损伤减轻,体重、血清中甘油三酯、总胆固醇、低密度脂蛋白胆固醇含量均显著下降,高密度脂蛋白胆固醇水平升高。实验表明,POL、EP8OL提取物能有效降低高脂小鼠体重,调节血脂水平,改善脂代谢紊乱,降低肝脏损伤程度。2种油橄榄叶提取物作用效果趋于一致,是潜在降低高血脂的天然活性产物,在保健领域具有重要研究意义和应用开发价值。

Study on the effect of extracts of E planting No.8 and Picual olive leaves on lowering blood lipid in hyperlipidemia mice

The purpose of this study is to investigate the intervention effect of Picual olive leaves(POL)and E planting No.8 olive leaves(EP8OL)extracts on body weight,liver damage and lipid reduction in hyperlipidemia mice,so as to provide data for the development of functional olive leave extract products.The hyperlipidemia mice model was established by feeding with a high-fat diet and the mice were divided into four groups,including blank group,control group,low-dose group,medium-dose group and high-dose group.The indexes were measured after four weeks of gavage.Compared with the control group,the results showed that the hyperlipidemia mice after 28 days’gavage significantly reduced their body weight,relieve liver damage and the levels of triglyceride(TG),total cholesterol(TCHO)and low-density lipoprotein cholesterol(LDL-C)in serum declined.Meanwhile,the high-density lipoprotein cholesterol(HDL-C)level in serum was raised.The results showed that both the POL and EP8OL extracts could effectively reduced the body weight and relieve liver damage,improved lipid metabolism disorder and reduced the level of blood lipid for the hyperlipidemia mice.In addition,there was little difference between the two kinds of olive leave extracts.They were potential natural activity products to improve hyperlipidemia.Therefore,the research of POL and EP8OL extract shows the very important significance and the exploration value is also important in the area of health care.