N,N′-二烯丙基二硫代二丙酰胺的合成及抑菌性能

以β-二硫代二丙酸二甲酯和烯丙基胺为原料,通过酰胺化反应合成了N,N′-二烯丙基二硫代二丙酰胺(ALPD),用红外光谱和核磁共振氢谱对ALPD结构进行了表征。探讨了反应物摩尔比、催化剂用量、β-二硫代二丙酸二甲酯滴加时间、反应时间对ALPD产率的影响;考察了ALPD的抑菌性能。结果表明,烯丙基胺为0.3mol,n(烯丙基胺)∶n(β-二硫代二丙酸二甲酯)=3∶1,催化剂三乙胺为2.5 mL,β-二硫代二丙酸二甲酯的滴加时间为2.5 h,反应时间为48 h,产率为88.4%。ALPD对大肠杆菌、金黄色葡萄球菌的最小抑菌质量浓度分别为0.125 0、0.062 5 g/L。ALPD中的双键可以通过聚合反应引入到大分子结构中。

Synthesis and Antibacterial Performance of N,N'-Di-Allyl-dithiodipropionamide

N,N′-Di-allyl-dithiodipropionamide(ALPD) has been synthesized from the starting materials of allylamine and dithiodipropionmethyl through amidation,and its structure has been confirmed by means of IR spectroscopy and 1HNMR.The effects of molar ratio of the reactants,amount of the catalyst,dropping time of dithiodipropionmethyl and reaction time on the yield of ALPD were investigated,and the antibacterial performance of ALPD was examined.The optimum reaction conditions are:n(allylamine)∶n(dithiodipropionmethyl)=3∶1,the amount of catalyst triethylamine is 2.5 mL,dropping time of dithiodipropionmethyl is 2.5 h,and the reaction time is 48 h.Under these optimum conditions,the yield is 88.4%.The MICs of ALPD are 0.125 0 g/L,0.062 5 g/L with Staphylococcus aureus,Escherichia coli.The ALPD can be introduced into the macromolecular structures through polymerization.