High-resolution echo-planar imaging at 3.0 T

Echo-planar imaging (EPI) is a snapshot technique, which is useful in a wide range of clinical applications, including the study of physiological function. Over recent years, EPI has found a major new use in functional imaging of the brain. Many EPI experiments can benefit from the increased signal-to-noise ratio (S/N) which results from imaging at high magnetic field. Recently, we have built a 3.0-T EPI scanner at Nottingham University. The low-level radiofrequency and control electronics have been constructed in-house. This, coupled with software written specifically for the system, results in a performance and flexibility exceeding that of a commercial system. A quiet head gradient set produces gradients of up to 30 mT m^–1. It is driven using a series multiresonant filter circuit, which allows the production of high-strength, trapezoidal- or sinusoidal-switched gradients.Using this scanner it has been possible to obtain images comprising 256×256 pixels, with a 2.5-mm slice and 0.75 mm in-plane resolution, in 140 ms. Multislicing allows a volume set of 16,128×128 images to be obtained in 1.6 s. A comparison of tests performed at fields of 0.5 T and 3.0 T on the same phantom indicates a better than linear increase in S/N with field strength. EPI images obtained at 3.0 T have been used in studies of brain activation during visual stimulation and execution of a simple motor task.