| 2-氨基-5-氟苯甲酸甲酯的合成 |
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| 引用本文： | 沈宁,衣志伟,刘骞峰,任增刚,刘嘉为,李乐,马科,郭阿敏.2-氨基-5-氟苯甲酸甲酯的合成[J].应用化工,2008,37(11). |
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| 作者姓名： | 沈宁 衣志伟 刘骞峰 任增刚 刘嘉为 李乐 马科 郭阿敏 |
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| 作者单位： | 西安瑞联近代电子材料有限责任公司,陕西,西安,710065 |
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| 摘 要： | 以3-氟苯甲酸为原料,通过酰化、酯化、硝化和还原一系列反应,成功得到目标产物2-氨基-5-氟苯甲酸甲酯。产品通过熔点测试、质谱确定结构,总收率达到40%,产品含量GC>99%,LC>98.5%。
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| 关 键 词： | 3-氟苯甲酸 2-氨基-5-氟苯甲酸甲酯 硝化 |
Synthesis of methyl 2-amino-5-fluorobenzaote |
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| SHEN Ning,YI Zhi-wei,LIU Qian-feng,REN Zeng-gang,LIU Jia-wei,LI Le,MA Ke,GUO A-min.Synthesis of methyl 2-amino-5-fluorobenzaote[J].Applied chemical industry,2008,37(11). |
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| Authors: | SHEN Ning YI Zhi-wei LIU Qian-feng REN Zeng-gang LIU Jia-wei LI Le MA Ke GUO A-min |
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| Abstract: | The new synthesis method of methyl 2-amino-5-fluorobenzaote was studied.Using 3-fluorobenzoic acid after a series of reactions of asylation,esterification,nitrification and hydronation,the TM was achieved,which structure was affirmed by melting point and GC-MS.The yield was 40%,GC>99%,LC>98.5%. |
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| Keywords: | 3-fluorobenzoic acid methyl 2-amino-5-fluorobenzaote nitrification |
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