| 3-氨基噻吩-2-甲酸乙酯的合成工艺研究 |
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| 引用本文： | 蒋达洪,蔡德娇,范芳.3-氨基噻吩-2-甲酸乙酯的合成工艺研究[J].应用化工,2011,40(6):1019-1021. |
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| 作者姓名： | 蒋达洪 蔡德娇 范芳 |
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| 作者单位： | 广东石油化工学院化学与生命科学学院,广东茂名,525000 |
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| 基金项目： | 广东石油化工学院博士启动科研基金 |
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| 摘 要： | 报道了一条以巯基乙酸和2-氯丙烯腈为原料经两步反应高产率合成3-氨基噻吩-2-甲酸乙酯的工艺路线,即巯基乙酸与乙醇酯化得到巯基乙酸乙酯,再在乙醇钠的作用下,与2-氯丙烯腈环合得到3-氨基噻吩-2-甲酸乙酯。后者通过在乙酸乙酯中与氯化氢气体生成非吸湿性盐进行分离提纯,两步总产率81%。
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| 关 键 词： | 3-氨基噻吩-2-甲酸乙酯 巯基乙酸乙酯 2-氯丙烯腈 合成工艺 |
Synthesis of ethyl 3-aminothiophene-2-carboxylate |
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| JIANG Da-hong,CAI De-jiao,FAN Fang.Synthesis of ethyl 3-aminothiophene-2-carboxylate[J].Applied chemical industry,2011,40(6):1019-1021. |
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| Authors: | JIANG Da-hong CAI De-jiao FAN Fang |
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| Affiliation: | JIANG Da-hong,CAI De-jiao,FAN Fang(Department of Chemical and Biological Sciences,Guangdong University of Petrochemical Technology,Maoming 525000,China) |
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| Abstract: | A practical and high-yield two-step procedure for the synthesis of ethyl 3-aminothiophene-2-carboxylate from mercaptoacetic acid and 2-chloroacrylonitrile through esterification and cyclocondensation was found and demonstrated.It was found that nonhygroscopic crystalline HCl salt of this amine provided a practical isolation point.The total yield in the two steps was 81%. |
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| Keywords: | ethyl 3-aminothiophene-2-carboxylate mercaptoacetic acid 2-chloroacrylonitrile procedure |
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