医药中间体2-对氯苄基吡啶的合成与分析

以对氯氯苄与盐酸吡啶缩合法制备2-对氯苄基吡啶.考察了用料配比、催化剂用量、反应时间、反应温度、保温时间等因素对产品收率的影响,确定了较佳工艺条件为n(对氯氯苄)∶n(盐酸吡啶)=1.6∶1.0,m(氯化铜)∶m(盐酸吡啶)=15∶100,反应温度160～170 ℃,反应时间2 h,保温时间7 h,无水吡啶加入量10 ml.在较佳反应条件下,2-对氯苄基吡啶的收率可达58.4%,并用气相色谱法程序升温分析该反应体系,效果良好.

Synthesis and Analysis of Medical Intermediate 2-(p-chlorobenzyl) Pyridine

p-chlorobenzyl) pyridine is prepared from 4-chlorobenzyl chloride and pyridine hydrochloride via condensation. The affection to the yield of some factors, such as material proportion, catalyst quantity, reaction time, reaction temperature and the persistent time of the temperature, are discussed, and the preferable process condition is determined. Under the preferable technological condition, the molar yield of 2-(p-chlorobenzyl) pyridine is about 58.4%. The resultants of the whole synthesis system are analyzed by gas chromatography with temperature programmable column oven, which gets ideal effects.