| 四丁基溴化铵催化合成2-甲基-2-苯基丙醇 |
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| 引用本文： | 王立冬,蔡东,贾云宏.四丁基溴化铵催化合成2-甲基-2-苯基丙醇[J].精细化工中间体,2010,40(4):43-45. |
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| 作者姓名： | 王立冬 蔡东 贾云宏 |
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| 作者单位： | 辽宁医学院,药学院,辽宁,锦州,121001 |
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| 摘 要： | 在相转移催化剂四丁基溴化铵存在下,以氯代叔丁基苯和氢氧化钠为原料合成2-甲基-2-苯基丙醇。分别研究了反应温度、反应时间、氢氧化钠浓度、催化剂用量等条件对合成反应的影响,优化了工艺条件:反应温度70℃,反应时间4 h,氢氧化钠浓度20%(m/m),催化剂用量3%(n/n,以氯代叔丁基苯计),收率68.7%。
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| 关 键 词： | 相转移催化 2-甲基2-苯基丙醇 合成 |
Preparation of 2-Methyl-2-phenyl-propan-1-ol with Phase-transfer Catalyst |
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| WANG Li-dong,CAI Dong,JIA Yun-hong.Preparation of 2-Methyl-2-phenyl-propan-1-ol with Phase-transfer Catalyst[J].Fine Chemical Intermediates,2010,40(4):43-45. |
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| Authors: | WANG Li-dong CAI Dong JIA Yun-hong |
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| Affiliation: | (College of Pharmaceutical Science,Liaoning Medical University,Jinzhou 121001,China) |
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| Abstract: | The synthesis of 2-methyl-2-phenyl-propan-1-ol by the reaction of 2-chloromethyl-2-phenylpropane and sodium hydroxide in the presence of tetrabutylammonium bromide was studied.The effects of the reaction temperature,the reaction time,the concentration of sodium hydroxide and amount of catalyst on the process were investigated,and the target compound was obtained in 68.7% yield under optimized reaction conditions（70℃,4 h,NaOH concentration 20%,catalyst load 3%）. |
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| Keywords: | phase-transfer catalyst 2-methyl-2-phenyl-propan-1-ol synthesis |
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