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| 5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-芳磺酸酯新型化合物的合成及生物活性 | |
| 引用本文： | 周红芳 沈德隆 孙国香 崔觉剑 屠美玲. 5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-芳磺酸酯新型化合物的合成及生物活性[J]. 精细化工中间体, 2007, 37(2): 28-29,70 |
| 作者姓名： | 周红芳 沈德隆 孙国香 崔觉剑 屠美玲 |
| 作者单位： | 浙江工业大学农药研究所 浙江杭州310032 |
| 摘 要： | 三唑类化合物具有广泛的生物活性。以2-羟基-5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶为原料,在缚酸剂存在下,于室温分别和苯磺酰氯、对甲苯磺酰氯进行酯化反应,合成了两个新型的5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-芳磺酸酯化合物a和b。产物经质谱、红外光谱、核磁共振谱确证。初步生物活性表明,该化合物具有一定的杀菌活性和除草活性,其中a有较高除草活性,而b对禾本科植物有较好的促进生长活性。 |
| 关 键 词： | 2-羟基-5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶 5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-芳磺酸酯 合成 生物活性 |
| 文章编号： | 1009-9212（2007）02-0028-02 |
| 修稿时间： | 2006-12-19 |
Synthesis and Bioactivity of Novel 2-(5,7-Dimethyl-1,2,4-triazole [1,5-a]pyrimidine) Benzenesulfonate Compounds |
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| ZHOU Hong-fang, SHEN De-long, SUN Guo-xiang, CUI Jue-jian, TU Mei-ling. Synthesis and Bioactivity of Novel 2-(5,7-Dimethyl-1,2,4-triazole [1,5-a]pyrimidine) Benzenesulfonate Compounds[J]. Fine Chemical Intermediates, 2007, 37(2): 28-29,70 | |
| Authors: | ZHOU Hong-fang SHEN De-long SUN Guo-xiang CUI Jue-jian TU Mei-ling |
| Affiliation: | Pesticide Research Institute, Zhejiang University of Technology, Hangzhou 310032, China |
| Abstract: | 1,2,4-Triazole derivatives are ertensively used in pharmaceutical and pesticide synthesis. Two new 2-(5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine) benzenesulfonate compounds a and b were synthesized from 2-hydroxyl-5,7-dimethyl-1,2,4-triazole[1,5-a] pyrimidine by cyclization and esterization,and their structures were confirmed by IR,UV and 1H NMR. Bioassay results showed that compound a and b exhibited fungicidal and herbicidal activity,which compound a had good herbicidal activity,and b had growth regulation activity. |
| Keywords: | 2-hydroxyl-5 7-dimethyl-1 2 4-triazole pyrimidine 2-hydroxyl-5 7-dimethyl-1 2 4-tria-zole pyrimidine) benzenesulfonate synthesis biological activity |
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