Nd掺杂硅酸钙及其复合电纺丝膜的制备及性能研究

同时具有光热效应与组织修复活性的生物材料在再生医学领域具有潜在应用前景。考虑到稀土元素Nd的荧光发光与光热双重特性, 结合钙硅基(Ca-Si)生物材料优异的组织修复活性, 有可能制备多功能组织损伤修复材料。本研究通过在硅酸钙中引入Nd元素, 采用共沉淀方法及800 ℃以上煅烧, 成功制备了Nd-Ca-Si基生物陶瓷粉体(Nd/CS), 并评价了粉体的物相组成、光热和荧光性能; 进一步采用静电纺丝技术制备了陶瓷粉体/高分子复合膜, 并评价了其理化性能与生物学性能。结果显示, Nd/CS陶瓷粉体和复合膜不但具有优异的光热性能与荧光性能, 还具有较好的荧光测温性能。细胞实验证实复合膜具有优良的生物学性能。这种集光热治疗、荧光成像/荧光测温、生物活性功能于一体的Nd-Ca-Si基生物陶瓷及其复合材料有望应用于再生医学领域。

Nd-doped Calcium Silicate: Photothermal Effect,Fluorescence Performance,and Biological Properties of Its Composite Electrospun Membrane

Biomaterials with photothermal effect and tissue repair activity have potential applications in the field of regenerative medicine. Considering the dual functions of fluorescence and photothermal effect of rare earth element Nd, and the excellent tissue repair biological activity of calcium-silicon (Ca-Si) based materials, here Nd-Ca-Si-based bioceramics (Nd/CS) powder we prepared by introducing Nd into calcium silicate through co-precipitation method and sintering at temperatures above 800 ℃, and evaluated phase composition, photothermal, and fluorescence properties of the powder. We further prepared a ceramic powder/polymer composite electrospun membrane, and evaluated its physical, chemical and biological properties. The results showed that Nd/CS ceramic powder and composite membrane not only had excellent photothermal performance and fluorescence emitting effects, but also showed fluorescence thermometry property. Preliminary cell experiments confirmed that the composite membrane was bioactive to stimulate fibroblast activity. This Nd-Ca-Si-based bioceramic and its composite material with integrated photothermal, fluorescence imaging/fluorescence thermometry properties and bioactivity, may have potential applications in regenerative medicine.