Atmospheric pressure photoionization mass spectrometry |
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Authors: | Raffaelli Andrea Saba Alessandro |
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Affiliation: | Dipartimento di Chimica e Chimica Industriale, CNR-Istituto di Chimica dei Composti Organo Metallici-Sezione di Pisa, Pisa, Italy. raffa@dcci.unipi.it |
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Abstract: | Atmospheric pressure photoionization (APPI) is the last arrival in the family of atmospheric pressure ionization (API) methods to couple mass spectrometry (MS) to liquid-phase separation techniques. The basic idea was to further extend the fields of application of liquid chromatography (LC)-MS to those molecules that are not, or are poorly amenable, to electrospray (ESI) or APCI. The present review explores the literature. After a short introduction with an historical background and the premises for its development, we describe the technique, its physical principles, and the factors that affect its efficiency. The review also presents a survey of applications in different fields. |
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Keywords: | photoionization atmospheric pressure ionization LC–MS |
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