| 羟丙基-β-环糊精的合成 |
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| 引用本文： | 胡文滨,夏建超,张文生,张增辉,左双燕.羟丙基-β-环糊精的合成[J].河北化工,2010(8):9-11. |
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| 作者姓名： | 胡文滨 夏建超 张文生 张增辉 左双燕 |
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| 作者单位： | 石药集团高科医药科技开发有限公司,河北,石家庄,052160 |
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| 摘 要： | 对羟丙基-β-环糊精（注射级）的合成路线进行了优化,结果显示,优化后的工艺成本较低,适用于工业生产,收率可达100%,平均取代度控制在4.0～5.0,β-环糊精残留控制在≤0.3%。
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| 关 键 词： | 羟丙基-β-环糊精 合成 收率 取代度 β-环糊精残留 |
Synthesis of Hydroxypropyl-beta-cyclodextrin |
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| HU Wen-bin,XIA Jian-chao,ZHANG Wen-sheng,ZHANG Zeng-hui,ZUO Shuang-yan.Synthesis of Hydroxypropyl-beta-cyclodextrin[J].Hebei Chemical Engineering and Industry,2010(8):9-11. |
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| Authors: | HU Wen-bin XIA Jian-chao ZHANG Wen-sheng ZHANG Zeng-hui ZUO Shuang-yan |
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| Affiliation: | (CSPC Shijiazhuang Gaoke Medical Technology Development Co.,Ltd,Shijiazhuang 052160,China) |
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| Abstract: | The synthetic route of HP-β-CD（injection grade） has been improved and optimized.The results show that the cost is lower than before.This is more applicable to industrial production.The yield can reach 100%,the DS（degree of substitution） is 4.0～5.0,and the residule of β-CD is not more than 0.3%. |
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| Keywords: | hydroxypropyl-beta-cyclodextrin synthesis yield substitute vestigital of beta-cyclodextrin |
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