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| 糖醇的选择性衍生-毛细管电泳检测法 | |
| 引用本文： | 张培,应津津,田艳萍.糖醇的选择性衍生-毛细管电泳检测法[J].广州化工,2014(18):156-158. |
| 作者姓名： | 张培 应津津 田艳萍 |
| 作者单位： | 1. 河南省药品审评认证中心,河南 郑州,450004 2. 浙江金华康恩贝生物制药有限公司,浙江 金华,321016 3. 武汉药品医疗器械检验所,湖北 武汉,430075 |
| 摘 要： | 建立了糖醇的CE-紫外衍生法:以三氧化二铝/甲烷磺酸为催化体系,苯甲酸为衍生化试剂,选择性酯化糖醇。以新型混合取代环糊精衍生物添加剂,分离检测不同糖醇。木糖醇、甘露醇、山梨醇、阿拉伯糖醇均得到较好分离,且木糖醇、甘露醇、山梨醇这三个糖醇的检测限分别达到9.1 ng/L,6.3 ng/L,10.2 ng/L。 |
| 关 键 词： | 糖醇 环糊精 毛细管电泳 |
Selective Derivatization and Determination of Sugar Alcohol by CE |
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| ZHANG Pei,YING Jin-jin,TIAN Yan-ping.Selective Derivatization and Determination of Sugar Alcohol by CE[J].GuangZhou Chemical Industry and Technology,2014(18):156-158. | |
| Authors: | ZHANG Pei YING Jin-jin TIAN Yan-ping |
| Affiliation: | ZHANG Pei, YING Jin-jin, TIAN Yan-ping ( 1 Henan Province for Evaluation Certification Center, Henan Zhengzhou 450004 ; 2 Zhejiang Jinhua CONBA Bio - pharm. Co. , Ltd. , Zhejiang Jinhua 321016 ; 3 Wuhan Institute for Drug and Medical Device Control, Hubei Wuhan 430075, China) |
| Abstract: | A method was developed for the selective benzoylation of sugar alcohol with Al 2 O3/Methylsulphonic acid as catalyst.One novel cyclodextrin derivatives was chosen as chiral selector for the separation and determination of different sugar alcohol.Under the experimental condition , xylitol, mannitol, sorbitol and arabitol were completely separated and the limits of quantification of xylitol , mannitol, sorbitol were 9.1 ng/L, 6.3 ng/L, 10.2 ng/L, respectively.Also, this method was successful in the chiral separation of arabinitol and the analysis of biological samples infected by systemic fungal. |
| Keywords: | sugar alcohol cyclodextrin CE |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |