B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity |
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| Authors: | Daniela Frasca Maria Romero Alain Diaz Denisse Garcia Seth Thaller Bonnie B Blomberg |
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| Affiliation: | 1.Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; (M.R.); (A.D.); (D.G.); (B.B.B.);2.Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA;3.Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA; |
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| Abstract: | Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation. |
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| Keywords: | B cells senescence inflammation obesity |
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