Carboxymethyl sago pulp/carboxymethyl sago starch hydrogel: Effect of polymer mixing ratio and study of controlled drug release |
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| Authors: | Hui Li Tan Yeon Yin Wong Saravanan Muniyandy Kamaruddin Hashim Janarthanan Pushpamalar |
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| Affiliation: | 1. School of Science, Monash University Malaysia, Subang Jaya,, Selangor Darul Ehsan, Malaysia;2. School of Pharmacy, Monash University Malaysia, Subang Jaya,, Selangor Darul Ehsan, Malaysia;3. Radiation Modification of Polymer Group, Radiation Processing Technology Division, Malaysian Nuclear Agency, Selangor Darul Ehsan, Malaysia |
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| Abstract: | Carboxymethyl sag o pulp (CMSP)/carboxymethyl sago starch (CMSS) hydrogel was synthesized by electron beam irradiation. In the series of hydrogels prepared, 40%/20% CMSP/CMSS hydrogel had the highest gel fraction. The swelling capacity of CMSP/CMSS hydrogel was found to be highest in distilled water, followed by pH 11, pH 7.4, and pH 1.2. Scanning Electron Microscope photographs revealed that the drug‐loaded hydrogel had a smoother surface than unloaded hydrogel. Fourier Transform Infrared and Differential Scanning Calorimetry analysis showed the absence of interaction between the hydrogels and the drug. All drug‐loaded hydrogels had drug encapsulation efficiency between 63% and 69%. CMSP/CMSS hydrogel swelled and allowed the release of drug at pH 7.4. These properties qualify the hydrogel as a potential candidate for controlled drug release at the ocular and colonic regions. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43652. |
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| Keywords: | biodegradable biopolymers & renewable polymers cross‐linking drug delivery systems irradiation |
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