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| 葫芦素B对四氯化碳致小鼠急性肝损伤的保护作用 | |
| 引用本文： | 杨世杰,昌友权,郑丽华,魏征人,曲红光,曹淑桂. 葫芦素B对四氯化碳致小鼠急性肝损伤的保护作用[J]. 食品科学, 2005, 26(9): 524-526 |
| 作者姓名： | 杨世杰 昌友权 郑丽华 魏征人 曲红光 曹淑桂 |
| 作者单位： | 1. 吉林大学基础医学院药理教研室,吉林,长春,130021 2. 吉林大学分子酶学工程教育部重点实验室,吉林,长春,130023;吉林工程技术师范学院生物与食品工程系,吉林,长春,130052 3. 吉林大学分子酶学工程教育部重点实验室,吉林,长春,130023 |
| 基金项目： | 长春市科技局新星创业计划项目（长科技合（2004283）号） |
| 摘 要： | 目的：探讨葫芦素B（Cucurbitacin B）对小鼠和大鼠实验性肝损伤的保护作用。方法：利用四氯化碳诱导小鼠和大鼠急性肝损伤模型，检测血清中GPT、GOT、ALP、TP、TBIL的含量，观察肝组织病理学改变。结果．各剂量组均可降低血清中GPT、GOT、ALP、TBIL的含量。结论：葫芦素B对CCL4所造成的肝损伤有一定的保护作用。 |
| 关 键 词： | 葫芦素B 四氯化碳 急性肝损伤 |
| 文章编号： | 1002-6630（2005）09-0524-03 |
| 收稿时间： | 2005-06-30 |
| 修稿时间： | 2005-06-30 |
Protective effects of Cucurbitacin B on the Acute Liver Injury Induced by CCL4 |
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| YANG Shi-jie,CHANG You-quan,ZHENG Li-hua,WEI Zheng-ren,QU Hong-guang,CHAO Shu-gui. Protective effects of Cucurbitacin B on the Acute Liver Injury Induced by CCL4[J]. Food Science, 2005, 26(9): 524-526 | |
| Authors: | YANG Shi-jie CHANG You-quan ZHENG Li-hua WEI Zheng-ren QU Hong-guang CHAO Shu-gui |
| Affiliation: | 1.The Pharmacology of Basic Medical School of Jilin University, Jilin Changchun 130021, China; 2.Key Laboratory of Molecular Enzymology and Engineering of Educational Ministry Jilin University,Changchun 130023,China; 3. Jilin Normal Institute of Engineering and Technology, Changchun 130052,China |
| Abstract: | Objective: To observe the protective effects of Cucurbitacin B on the liver injery in mice and rats. Methods: The model of acute liver injury in mice and rats were induced by CCL4, the content of GPT, GOT, ALP, TP, TBIL in serum were measured.The change of liver histopathology were observed.Results each group can reduce the content of GPT, GOT, ALP, TBIL in serum. Conclusion: Cucurbitacin B has the protective effects on the liver injury induced by CCL4. |
| Keywords: | melon vines effective part tetrachloride acute liver injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |