以药物结构为核心的药物化学教学设计

药物化学知识体系的形成和发展与有机化学、生物化学、分子生物学等基础学科息息相关,综合性强,且存在药物种类繁多、药物理化性质复杂、构效关系与作用机制不易理解等问题。本文通过以药物结构为教学核心,构建药物化学知识网,旨在克服教学过程中上述问题,避免知识点罗列的灌输性教学,降低教学难度和学习难度,并引导学生进一步掌握药物的构效关系、药理作用,讲解新药研发的创新思路,培养学生设计新药的思维。

Teaching Design of Medicinal Chemistry with Drug-Structure-Centered Method

The formation and development of the knowledge system of medicinal chemistry were closely related to organic chemistry,biochemistry and molecular chemistry. The complicate drug physical and chemical properties,the intricate structure- activity relationship and the complex mechanism of a variety of drugs contributed to the difficulty in learning this comprehensive course. A successful endeavor in drug- structure- centered teaching method was made to reduce the degree of difficulties of both teaching and learning. Furthermore,students were guided in mastering the structure- activity relationship and pharmacological effects of various drugs with the approach and their ideation in design new drugs were cultivated by interpreting the innovative ideas of drug research and development.