| 一种环胺的十一烷酸衍生物作为心肌显像剂的尝试 |
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| 引用本文： | 李毕忠,王祥云.一种环胺的十一烷酸衍生物作为心肌显像剂的尝试[J].核化学与放射化学,1990,12(1):46-50,64. |
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| 作者姓名： | 李毕忠 王祥云 |
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| 作者单位： | 北京大学技术物理系
(李毕忠，王祥云)，北京大学技术物理系(刘元方) |
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| 摘 要： | 为了寻找新的心肌显像剂,合成了新的大环配体反-5,7,7,12,14,14-六甲基-N,N″-二(正十一烷酸)-1,4,8,11-四氮杂环十四烷(缩写为Teta-DUA)及其二乙酯(缩写为Teta-DUAE),并作了表征。采用氯化亚锡还原法将(~99m)Tc标记在Teta-DUA和Teta-DUAE上。~(99m)Tc-Teta-DUA和。~(99m)Tc-Teta-DuAE在小鼠心肌的最高浓集分别为0.09％I.D./心脏、0.90％I.D./g心肌和1.6％I.D./心脏、1.4％I.D./g心肌。
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| 关 键 词： | 锝 大环配体 心肌显像剂 生物分布 |
AN UNDECANE ACID DERIVATIVE OF A CYCLOAMINE AS A POTENTIAL MYOCARDIAL IMAGING AGENT |
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| LI BIZHONG WANG XIANGYUN LIU YUANFANG.AN UNDECANE ACID DERIVATIVE OF A CYCLOAMINE AS A POTENTIAL MYOCARDIAL IMAGING AGENT[J].Journal of Nuclear and Radiochemistry,1990,12(1):46-50,64. |
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| Authors: | LI BIZHONG WANG XIANGYUN LIU YUANFANG |
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| Abstract: | In order to search for a new myocardial imaging agent, trans-5 ,7 ,7 ,12 ,14, 14-hexamethyl-N, N'-di (undecane acid) -1,4,8, 11-tetraazacyclotetradecaneContinued on p. 64) (Teta-DUA) and its diethyl ester (Teta-DUAE) are synthesized and characterized in this study. The complexes of these ligands with99To, 99mTc-Teta-DUA and 99mTc-Teta-DUAE are prepared by the reduction of 99mTc07 with stannous chloride. The highest heart uptakes of 99mTc-Teta-DUA and 99mTc-Teta-DUAE in Swiss mice are 0.09% I. D./heart, 0.90% I. D./gram heart muscle and 0.16% I. D./heart, 1.4% I. D./gram heart muscle respectively, which occur at 10 and 30 minutes after intravenous injection respectively. |
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| Keywords: | Technetium Macrocyclic ligand Myocardial imaging agent Biodistribution |
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